Co-amoxiclav (amoxicillin & clavulanic acid). Per 625 mg tab Amoxicillin trihydrate 500 mg, clavulanate K 125 mg. Per 1 g tab Amoxicillin trihydrate 875 mg, clavulanate K 125 mg. Per 228 mg/5 mL syr Amoxicillin trihydrate 200 mg, clavulanate K 28 mg. Per 457 mg/5 mL syr Amoxicillin trihydrate 400 mg, clavulanate K 57 mg
Max amoxicillin daily dose: Adult 6 g, childn 45 mg/kg. Max clavulanic acid daily dose: Adult 600 mg, childn 10 mg/kg. TabAdult & childn >12 yrMild to moderate infections 375 mg tid or 625 mg bid. Severe infections 625 mg tid or 1 g every 12 hr. Moderate renal insufficiency w/ CrCl 10-30 mL/min 625 mg every 12 hr, severe renal insufficiency w/ CrCl <10 mL/min 625 mg every 24 hr. 228 mg/5 mL & 457 mg/5 mL syrChildn weighing <40 kg 25-45 mg/kg daily in 2 equally divided doses. Otitis sinusitis, lower resp tract infections & other severe infections 45 mg/kg daily every 12 hr. Moderate infections 25 mg/kg daily every 12 hr.
Administration
May be taken with or without food: Best taken at the start of meals for better absorption & to reduce GI discomfort.
Contraindications
Hypersensitivity to amoxicillin, clavulanic acid, penicillins. Infectious mononucleosis, lymphatic leukemia.
Special Precautions
History of allergic reactions. Infectious mononucleosis, cholestatic jaundice. Severe hepatic & renal impairment. Pregnancy & lactation. Not to give tab in childn <12 yr.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
Sign Out
