Amlopine Dosage/Direction for Use

Recommended Doses: Adult: Hypertension: initial, 5 mg orally once daily; maintenance 5-10 mg orally once daily.
Stable angina: 5-10 mg orally once daily.
Variant angina: 5-10 mg orally once daily.
Coronary artery disease: 5-10 mg orally once daily.
Pediatric: Safety and efficacy not established in pediatric patients younger than 6 years of age.
Hypertension: 6 to 17 years of age, 2.5-5 mg orally once daily.
Dosage in Geriatric Patients: Begin therapy at 2.5 mg daily for hypertension and 5 mg for angina.
Dosage in Renal Failure: Dosage adjustments of amlodipine are not required in patients with renal impairment.
Dosage in Hepatic Insufficiency: Amlodipine is extensively metabolized in the liver, which results in a slight reduction of clearance in the presence of hepatic impairment. Dosage adjustments may be required in patients with liver disease. Begin therapy at 2.5 mg daily for hypertension and 5 mg for angina.
Dosage Adjustment During Dialysis: Hemodialysis: The pharmacokinetics of amlodipine have not been significantly altered in hemodialysis patients, and dosage adjustments do not appear to be required.
Peritoneal Dialysis: Dosage adjustments are not needed for chronic ambulatory peritoneal dialysis.
Mode of Administration: Oral: may be administered without regard to meals.