AmBisome Indications/Uses

Treatment of systemic mycotic infections due to organisms susceptible to AmBisome eg, cryptococcosis, North American blastomycosis, disseminated candidiasis, coccidioidomycosis, aspergillosis, histoplasmosis, mucormycosis and in the treatment of some cases of American mucocutaneous leishmaniasis.
Treatment of fever of unknown origin (FUO) in neutropenic patients. In this context, FUO is defined as persisting fever, unresponsive to at least 96 hrs of antibiotic treatment; it is highly indicative of a systemic fungal infection in this patient population. Before initiating AmBisome treatment, common viral, parasitic or mycobacterial infections should also be excluded as far as possible as causes for the observed FUO.
Primary therapy of visceral leishmaniasis in immunocompetent patients including both adults and children and in immunocompromised patients (eg, HIV-positive).
AmBisome should not be used to treat the common clinically inapparent forms of fungal disease which show only positive skin or serologic tests.