IV Max inj rate: 10 mL/min.
Adult & adolescent ≥12 yr On-demand treatment Individualised dose.
Early haemarthrosis, muscle or oral bleeding 20-40 IU/dL required factor VIII level. Repeat inj every 12-24 hr for at least 1 day until bleeding episode as indicated by pain is resolved or healing is achieved.
More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU/dL required factor VIII level. Repeat inj every 12-24 hr for ≥3-4 days until pain & acute disability are resolved.
Life-threatening haemorrhages 60-100 IU/dL required factor VIII level. Repeat inj every 8-24 hr until threat is resolved.
Minor surgery including tooth extraction 30-60 IU/dL required factor VIII level. Inj every 24 hr for at least 1 day until healing is achieved.
Major surgery (pre- & post-op) 80-100 IU/dL required factor VIII level. Repeat inj every 8-24 hr until adequate wound healing, then for at least another 7 days to maintain 30-60% factor VIII activity.
Prophylaxis 20-50 IU/kg 2-3 times wkly.
Childn 0 to <12 yr 30-50 IU/kg 2-3 times wkly.
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