Post-menopausal women w/ hormone receptor-+ve & HER-2 -ve advanced breast cancer in combination w/ exemestane after failure of treatment w/ letrozole or anastrozole. Advanced neuroendocrine tumors of pancreatic origin. Advanced renal cell carcinoma after failure of therapy w/ sunitinib or sorafenib or after treatment w/ VEGF targeted therapy.
View Afinitor overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: Take consistently either w/ or w/o food. Swallow whole w/ a glass of water, do not chew/crush. Avoid grapefruit products.
Non-infectious pneumonitis, infections, hypersensitivity reactions. Avoid alcohol- or peroxide-containing mouthwashes in case of oral ulceration. Monitor renal function, blood glucose & CBC. Severe hepatic impairment (Child-Pugh class C). Avoid use of live vaccines. Childn <18 yr. Pregnancy & lactation. Male fertility may be compromised.
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