Patient ≥18 yr w/ CrCl >50 mL/min cIAI 1.5 g every 8 hr w/ 1 hr infusion time for 4-14 days in conjunction w/ metronidazole 500 mg IV every 8 hr.
cUTI including pyelonephritis 1.5 g every 8 hr w/ 1 hr infusion time for 7 days.
Nosocomial pneumonia including VAP 3 g every 8 hr w/ 1 hr infusion time for 8-14 days.
Renal impairment: CrCl 30-50 mL/min cIAI & cUTI including pyelonephritis 750 mg IV every 8 hr w/ 1 hr infusion time.
Nosocomial pneumonia including VAP 1.5 g IV every 8 hr w/ 1 hr infusion time.
CrCl 15-29 mL/min cIAI & cUTI pyelonephritis 375 mg IV every 8 hr w/ 1 hr infusion time.
Nosocomial pneumonia including VAP 750 mg IV every 8 hr w/ 1 hr infusion time.
ESRD on hemodialysis cIAI & cUTI including pyelonephritis 750 mg single loading dose followed by 150 mg maintenance dose every 8 hr for the remainder of treatment period.
Nosocomial pneumonia including VAP 2.25 g single loading dose followed by 450 mg maintenance dose every 8 hr for the remainder of treatment period.
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