Fe deficiency where there is a clinical need for a rapid Fe supply; in patients who cannot tolerate oral Fe therapy or non-compliant; where oral Fe prep are ineffective (eg, active inflammatory bowel disease).
IV Individualized dosage. Adults 100-200 mg 1-3 times a wk. Childn Max: 3 mg/kg 3 times a wk. Inj Max tolerated daily dose: 200 mg over at least 10 min, to be given not more than 3 times a wk. Infusion Patient weighing >70 kg Max tolerated daily dose: 500 mg over at least 3 ½ hr, to be given not more than once a wk, ≤70 kg Max tolerated daily dose: 7 mg/kg over at least 3 ½ hr, to be given not more than once a wk.
Potentially fatal allergic or anaphylactoid reactions; risk of allergic reaction in patients w/ history of asthma, eczema, other atopic allergies or allergic reactions to other parenteral Fe prep. Observe for adverse effects for at least 30 min following each inj. Possible progression of hypersensitivity reactions to Kounis syndrome. Patients w/ acute or chronic infection; stop administration in patients w/ bacteraemia. Avoid paravenous leakage; immediately stop administration when pain, inflammation, tissue necrosis & brown skin discoloration occur. Patients w/ liver dysfunction. Carefully monitor Fe status to avoid Fe overload. Pregnancy (2nd & 3rd trimester). Lactation.
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