The natriuretic effect of frusemide has been reported to be inhibited by some drugs in this class. Inhibition of renal lithium clearance leading to increase in plasma lithium concentrations has also been reported. Due to the high plasma protein binding of naproxen sodium, patients simultaneously receiving hydantoins should be closely monitored for adjustments of dose if required. Probenecid given concurrently increases naproxen plasma levels and extends its plasma half life significantly. Naproxen sodium can reduce the anti-hypertensive effect of propanolol and other beta-blockers.
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