Soliris Caution For Usage

Incompatibilities: This medicinal product must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling as follows.
Special precautions for disposal and other handling: Prior to administration, the SOLIRIS solution should be visually inspected for particulate matter and discolouration.
Instructions: Reconstitution and dilution should be performed in accordance with good practices rules, particularly for the respect of asepsis.
Withdraw the total amount of SOLIRIS from the vial(s) using a sterile syringe.
Transfer the recommended dose to an infusion bag.
Dilute SOLIRIS to a final concentration of 5 mg/ml by addition to the infusion bag using sodium chloride 9mg/ml (0.9%) solution for injection, sodium chloride 4.5mg/ml (0.45%) solution for injection, or 5% Dextrose in water, as the diluent.
The final volume of a 5 mg/ml diluted solution is 60 ml for 300 mg doses, 120 ml for 600 mg doses, 180 ml for 900 mg doses and 240 ml for 1,200 mg doses. The solution should be clear and colourless.
Gently agitate the infusion bag containing the diluted solution to ensure thorough mixing of the product and diluent.
The diluted solution should be allowed to warm to room temperature prior to administration by exposure to ambient air.
Discard any unused portion left in a vial, as the product contains no preservatives.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.