Sign Out
Hyponatremia: The treatment of clinically significant hypervolemic and euvolemic hyponatremia [serum sodium < 125 mEq/L or hyponatremia that is symptomatic and has resisted correction with fluid restriction], including patients with heart failure, and Syndrome of Inappropriate Antidiuretic Hormone (SIADH).
Adjunct Treatment of Volume Overload in Heart Failure: Volume overload in heart failure when adequate response is not obtained with other diuretics (e.g., loop diuretics).
Limitations of Use: When conditions or symptoms due to volume overload are resolved, administration of SAMSCA should be discontinued. The efficacy and safety of SAMSCA for maintenance treatment following resolution have not been established. In a clinical study, 15 mg tolvaptan has been associated with worse clinical outcomes vs placebo when rated at 6 months (last visit).
