Rebif Description

Each Rebif 22 micrograms solution for injection in cartridge contains 66 micrograms (18 MIU*) of interferon beta-1a** in 1.5 ml solution, corresponding to 44 micrograms/ml.
*Million International Units, measured by cytopathic effect (CPE) bioassay against the in-house IFN beta-1a standard which is calibrated against the current international NIH standard (GB-23-902-531).
**Produced in Chinese hamster ovary Cells (CHO-K1) by recombinant DNA technology.
Excipient with known effect: Contains 2.5 mg benzyl alcohol per dose of 0.5 mL.
Each Rebif 44 micrograms solution for injection in cartridge contains 132 micrograms (36 MIU*) of interferon beta-1a** in 1.5 ml solution corresponding to 88 micrograms/ml.
*Million International Units, measured by cytopathic effect (CPE) bioassay against the in-house IFN beta-1a standard which is calibrated against the current international NIH standard (GB-23-902-531).
**Produced in Chinese hamster ovary Cells (CHO-K1) by recombinant DNA technology.
Rebif has a pH of 3.7 to 4.1 and osmolarity 250 to 450 mOsm/l.
Excipients/Inactive Ingredients: Mannitol, Poloxamer 188, L-methionine, Benzyl alcohol, Sodium acetate, Acetic acid for pH adjustment, Sodium hydroxide for pH adjustment, Water for injections.