Rapamune Description

Rapamune (sirolimus) is an immunosuppressive agent. Sirolimus is a macrocyclic lactone produced by Streptomyces hygroscopicus.
Chemical Name: The chemical name of sirolimus (also known as rapamycin) is (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4] oxaazacyclohentriacontine-1,5,11,28,29 (4H,6H,31H)-pentone.
Molecular Formula: Its molecular formula is C₅₁H₇₉NO₁₃.
Molecular Weight: Its molecular weight is 914.2.
Physical Characteristics: Sirolimus is a white to off-white powder and is insoluble in water, but freely soluble in benzyl alcohol, chloroform, acetone, and acetonitrile.
Excipients/Inactive Ingredients: The inactive ingredients in Rapamune Tablets include sucrose, lactose monohydrate, polyethylene glycol 8000 powdered, calcium sulfate anhydrous, microcrystalline cellulose, pharmaceutical glaze (shellac solution 4# cut), talc, titanium dioxide, magnesium stearate, povidone (K29/32), poloxamer 188, polyethylene glycol (macrogol) type 20,000, glyceryl monooleate (60%), carnauba wax, vitamin E (dl-alpha tocopherol), alcohol denatured 23A*, water purified*, mineral spirits odorless, ink-red opacode S-1-15095 and water for injection*.
*Removed during processing. Does not appear in the finished dosage form.