Hypersensitivity to simvastatin or to any of the other components of Priacin.
Active liver disease or unexplained persistent elevations of serum transaminases.
Pregnancy and lactation.
Concomitant administration of potent CYP3A4 inhibitors (eg, itraconazole, ketoconazole, posaconazole, voriconazole, HIV protease inhibitors, boceprevir, telaprevir, erythromycin, clarithromycin, telithromycin and nefazodone) and gemfibrozil, cyclosporine or danazol (see Interactions).