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Sympathomimetics should be used with caution in patients with hypertension, hyperthyroidism, diabetes mellitus and cardiovascular disease. Antihistamines should be used with caution in patients with narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy and bladder neck obstruction.
Antihistamines have additive effects with alcohol and other CNS depressants.
Patients should be warned about engaging in activities requiring mental alertness such as driving a car or operating machinery.
