Olvion Dosage/Direction for Use

Adults: Recommended Dose: 50 mg taken as needed approximately 1 hr before sexual activity.
Based on effectiveness and tolerance, the dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg. The maximum recommended daily dose is 100 mg. The maximum recommended dosing frequency is once per day.
Patients with Impaired Renal Function: Dosage adjustments are not required in patients with mild to moderate renal impairment [creatinine clearance (CrCl)=30-80 mL/min].
Since sildenafil clearance is reduced in patients with severe renal impairment (CrCl <30 mL/min) a 25 mg dose should be considered.
Patients with Impaired Hepatic Function: Since sildenafil clearance is reduced in patients with hepatic impairment (eg, cirrhosis) a 25 mg dose should be considered.
Patients Using Other Medication: Given the extent of the interaction with patients receiving concomitant therapy with ritonavir (see Interactions), co-administration with ritonavir is not advised. If ritonavir is co-administered with sildenafil, it is recommended not to exceed a maximum single dose of 25 mg of sildenafil in a 48-hr period.
A starting dose of 25 mg should be considered in patients receiving concomitant treatment with the CYP3A4 inhibitors (eg, erythromycin, saquinavir, ketoconazole, itraconazole) (see Interactions).
In order to minimize the potential for developing postural hypotension, patients should be stable on α-blocker therapy prior to initiating sildenafil treatment. In addition, initiation of sildenafil at lower doses should be considered (see Precautions and Interactions).
Elderly Men: Since sildenafil clearance is reduced in elderly patients, a 1st dose of 25 mg should be considered.
Administration: Sildenafil tablets are for oral administration.