Individualized dosage. Usual recommended starting dose: 20 mg once daily when used as monotherapy in patients who are not vol-contracted. May be increased to 40 mg daily after 2 wk if necessary.
Symptomatic hypotension may occur particularly in vol- &/or salt-depleted patients. Sprue-like enteropathy; discontinue use if severe, chronic diarrhea w/ substantial wt loss develops. Periodically monitor serum electrolytes. Not recommended to be combined w/ ACE-inhibitors, AIIA. Renal impairment; severe CHF; oliguria &/or progressive azotemia. Possible increase in serum creatinine or BUN in patients w/ unilateral or bilateral renal artery stenosis. Lactation. Childn.
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