Discontinue use & initiate appropriate therapy if hypersensitivity reaction occurs. Discontinue use if medication overuse headache occurs. Avoid another dose w/in 48 hr when concomitantly administered w/ moderate CYP3A4 inhibitors. Not recommended for concomitant use w/ strong CYP3A4 inhibitors; strong or moderate CYP3A4 inducers. Severe renal impairment; dialysis patients. Not recommended in patients w/ severe hepatic impairment; ESRD (CrCl <15 mL/min). Avoid use during pregnancy. Lactation. Paed <18 yr. Elderly ≥65 yr.
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