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NESP is the Kyowa Kirin Co. trademark for darbepoetin alfa (rch), a novel erythropoiesis stimulating protein produced by recombinant DNA technology.
NESP (darbepoetin alfa) is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. NESP stimulates red blood cell production (erythropoiesis) by the same mechanism as recombinant human erythropoietin (r-HuEPO). NESP is a 165-amino acid protein containing 5 N-linked oligosaccharide chains, whereas erythropoietin contains only 3. The additional carbohydrate chains increase the molecular weight of the glycoprotein to approximately 36,000 daltons.
NESP contains ingredients as follows: Each injection syringe (0.5 mL) contains ingredients as follows: (See Table 1.)
Click on icon to see table/diagram/image