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Concomitant use of probenecid is not recommended. Probenecid decreases the renal tubular secretion of amoxicillin. Concomitant use with Moxiclav may result in increased and prolonged blood levels of amoxicillin but not of clavulanate.
Concomitant use of allopurinol during treatment with amoxicillin can increase the likelihood of allergic skin reactions. There are no data on the concomitant use of Moxiclav and allopurinol.
In common with other antibiotics, Moxiclav may affect the gut flora, leading to lower oestrogen reabsorption and reduced efficacy of combined oral contraceptives.
Concurrent administration of amoxicillin with tetracycline antibiotics decreases the bactericidal action of amoxicillin.
Drug Laboratory Interactions: False-positive results may be obtained when testing for the presence of glucose in urine, using a copper-sulfate reagent.
