Per 375 mg tab Amoxicillin trihydrate 250 mg, K clavulanate 125 mg. Per 625 mg tab Amoxicillin trihydrate 500 mg, K clavulanate 125 mg. Per 1 g tab Amoxicillin trihydrate 875 mg, K clavulanate 125 mg. Per 5 mL susp Amoxicillin trihydrate 125 mg, K clavulanate 31.25 mg. Per 5 mL forte susp Amoxicillin trihydrate 250 mg, K clavulanate 62.5 mg
Adult & childn >14 yrMild to moderate infection 375-mg tab tds or 625-mg tab bd. Severe infection 625-mg tab tds or 1-g tab bd. Childn 7-14 yr 10 mL susp or 5 mL forte susp tds, 2-7 yr 5 mL susp tds, 9 mth-2 yr 2.5 mL susp every 8 hr, <2 yr Max clavulanic acid dose: 5 mg/kg daily. Max duration of treatment: 14 days. Renal impairment in adult: Moderate (CrCl 10-30 mL/min) 375-mg tab or 625-mg tab every 12 hr, severe (CrCl <10 mL/min) Max: 375-mg tab every 12 hr.
Discontinue use & institute appropriate alternative therapy if allergic reactions occur. Avoid use if infectious mononucleosis is suspected. Overgrowth of non-susceptible organisms during prolonged use. Prolonged bleeding & prothrombin time. Possible cholestatic jaundice; signs & symptoms may not become apparent for up to 6 wk after treatment. Crystalluria may be observed in patients w/ reduced urine output. Maintain adequate fluid intake & urinary output. Renal impairment. Monitor hepatic function at regular intervals. Patients w/ evidence of hepatic dysfunction. Avoid use during pregnancy especially during 1st trimester. Do not administer in patient w/ sensitization risk during lactation period. Do not increase dosage for severe infections in childn. Not recommended for childn w/ CrCl <30 mL/min.
May increase & prolong amoxicillin blood levels by probenecid. May increase risk of allergic skin reactions w/ allopurinol. May lower oestrogen reabsorption & reduce efficacy of combined OCs. Decreased amoxicillin bactericidal action w/ tetracyclines. False +ve results when testing for the presence of glucose in urine using Cu sulfate reagent.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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