Minirin Overdosage

Overdose of MINIRIN leads to prolonged duration of action with an increased risk of water retention and hyponatraemia.
Nasal spray: Even normal doses may cause water intoxication in association with a high fluid intake. Doses exceeding 0.3 μg/kg i.v. and 2.4 μg/kg intranasally have together with fluid intake caused hyponatraemia and convulsions in children and adults.
Symptoms: The same symptoms as for water intoxication. Headache, nausea. Fluid retention, hyponatraemia, hypoosmolality, oliguria, CNS depression, convulsions, pulmonary oedema. See Adverse Reactions.
Treatment: Tablet: Although the treatment of hyponatremia should be individualized, the following general recommendations can be given. Asymptomatic hyponatremia is treated with discontinuing the desmopressin treatment and fluid restriction. Infusion of isotonic or hypertonic sodium chloride may be added in cases with symptoms. When the water retention is severe (convulsions and unconsciousness) treatment with furosemide should be added.
Nasal spray: The treatment of hyponatraemia must be tailored to the individual, but the following general recommendations may be given.
Hyponatraemia is treated by discontinuing the desmopressin treatment and restricting fluids. If the patient has symptoms, an infusion of isotonic or hypertonic sodium chloride may be given. When the fluid retention is serious (convulsions and loss of consciousness), treat with furosemide.