Central diabetes insipidus Tab Adult & childn Initially 0.1 mg tds then adjusted according to the response of the patient. Optimal dose regimen: 0.1-0.2 mg tds for most patients.
Oral lyophilisate Individualized dosage. Total daily dose: 120-720 mcg.
Adult & childn Initially 60 mcg SL tds. Maintenance: 60-120 mcg SL tds.
IV inj Adult 1-4 mcg (0.25-1 mL) once daily-bd.
Childn >1 yr 0.4-1 mcg (0.1-0.25 mL) once daily-bd.
Infant <1 yr 0.2-0.4 mcg (0.05-0.1 mL) once daily-bd.
Nasal spray Adult 10-20 mcg 1-2 times daily.
Childn 5-10 mcg 1-2 times daily.
Primary nocturnal enuresis Tab Initially 0.2 mg at bedtime, may be increased up to 0.4 mg if dose is not sufficiently effective.
Oral lyophilisate Initially 120 mcg SL at bedtime, may be increased up to 240 mcg SL. Duration of treatment: Up to 3 mth.
Renal concentrating capacity test IM/SC inj Adult 4 mcg (1 mL).
Childn >1 yr 1-2 mcg (0.25-0.5 mL).
Infant <1 yr 0.4 mcg (0.1 mL).
Nasal spray Adult 40 mcg.
Childn >1 yr 20 mcg.
Infant <1 yr 10 mcg.
Therapeutic control of bleeding & bleeding prophylaxis in Haemophilia A & von Willebrand's disease IV inj 0.3 mcg/kg slow IV infusion over 15-30 min.
Adult & childn weighing ≥10 kg Use 50 mL of diluent,
<10 kg Use 10 mL of diluent. If +ve effect is obtained, the initial dose may be repeated 1-2 times w/ interval of 6-12 hr.