SC/IM Women w/ anovulation (including PCOD) Therapy should start w/in the initial 7 days of the menstrual cycle. Initially 75-150 IU daily, maintained for at least 7 days. Recommended dose increment: 37.5 IU/adjustment up to 75 IU. Max daily dose: 225 IU.
Women undergoing controlled ovarian hyperstimulation for multiple follicular development for ART Therapy should start approx 2 wk after the start of agonist treatment. Initially 150-225 IU daily for at least 1st 5 days of treatment. Dose adjustment should not exceed >150 IU/adjustment. Max daily dose: 450 IU daily. Max duration: 20 days.
Women w/ hypo- or normogonadotropic ovarian insufficiency Initially 75-150 IU/day. Dose may be increased gradually until there is evidence of estradiol secretion or follicular growth. Maintain dose until pre-ovulation estradiol serum level achieved. To induce ovulation, administer 5,000-10,000 IU hCG via IM inj 1-2 days after the last dose of HMG.
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