Mabron Special Precautions

Mabron should be used with care in patients with increased reactivity to opioids.
Injection: It should be given with caution or in reduced doses to patients with hypothyroidism, adrenocortical insufficiency, kidney or liver impairment, prostatic hypertrophy or shock; obstructive bowel disorders and myasthenia gravis.
Respiratory depression has so far not been observed during treatment with Mabron. However, it cannot definitely be ruled out if the recommended dosage is considerably exceeded or on the concomitant administration of other centrally depressant drugs.
Effects on the Ability to Drive or Operate Machinery: Even when taken according to instructions, Mabron may affect the reaction ability of the patient to such an extent that his capacity to drive or operate machines may be impaired. This applies particularly in conjunction with alcohol.
Use in pregnancy & lactation: In accordance with currently prevailing recommendations, medication with Mabron should only be resorted to during pregnancy after careful consideration of the risks. So far, no reports are available on its use during lactation.