Klerimed Contraindications

Hypersensitivity to clarithromycin, macrolide antibiotic drugs or any of the excipients of Klerimed.
Concomitant administration of clarithromycin and any of the following drugs is contraindicated: Astemizole, cisapride, pimozide, terfenadine as this may result in QT prolongation and cardiac arrhythmias, including ventricular tachycardia, ventricular fibrillation and Torsades de pointes (see Interactions).
Concomitant administration of clarithromycin and ergot alkaloids (eg, ergotamine or dihydroergotamine) is contraindicated, as this may result in ergot toxicity (see Interactions).
Concomitant administration of clarithromycin and oral midazolam is contraindicated (see Interactions).
Clarithromycin should not be given to patients with history of QT prolongation or ventricular cardiac arrhythmia, including Torsades de Pointes (see Precautions and Interactions).
Patients with hypokalemia (risk of prolongation of QT-time); who suffer from severe hepatic failure in combination with renal impairment.
Should not be used concomitantly with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) that are extensively metabolized by CYP3A4 (lovastatin or simvastatin), due to the increased risk of myopathy, including rhabdomyolysis (see Precautions).
Clarithromycin (and other strong CYP3A4 inhibitors) should not be used concomitantly with colchicine in patients with renal or hepatic impairment (see Precautions and Interactions).