Sign Out
Tremelimumab is an immunoglobulin and the primary elimination pathways of tremelimumab are protein catabolism via reticuloendothelial system or target-mediated disposition; therefore, no formal pharmacokinetic (PK) drug-drug interaction studies have been conducted with tremelimumab since no metabolic drug-drug interactions are expected. PK drug-drug interaction between tremelimumab in combination with durvalumab was assessed in the HIMALAYA study and no clinically meaningful PK drug-drug interaction was identified.
The use of systemic corticosteroids or immunosuppressants before starting tremelimumab, except physiological dose of systemic corticosteroids (≤ 10 mg/day prednisone or equivalent), is not recommended because of their potential interference with the pharmacodynamic activity and efficacy of tremelimumab. However, systemic corticosteroids or other immunosuppressants can be used after starting tremelimumab to treat immune-related adverse reactions.
