Appropriate medical treatment & supervision should be available in case of anaphylactic reaction following vaccination. Do not administer intravascularly, intradermally or SC. No protection against hepatitis infection caused by other agents eg, hepatitis A, C & E or other liver pathogens; other types of
H. influenzae or meningitis of other origins. Postpone immunisation in individuals suffering from moderate to severe acute febrile illness or infection. Carefully consider giving further doses if temp ≥40°C w/in 48 hr of vaccination not due to another identifiable cause; collapse or shock-like state (hypotonic-hyporesponsive episode) w/in 48 hr of vaccination; persistent, inconsolable crying lasting ≥3 hr w/in 48 hr of vaccination; convulsions w/ or w/o fever occurring w/in 3 days of vaccination. Post-vaccination in individuals w/ history of febrile convulsions. Carefully consider use if Guillain-Barré syndrome or brachial neuritis occurred following receipt of prior tetanus toxoid containing vaccine. Possible multiple sclerosis after hepatitis B vaccination. May reduce vaccine immunogenicity by immunosuppressive treatment or immunodeficiency. Immune response to vaccine in context of genetic polymorphism. Possible impaired hepatitis B response in individuals w/ chronic renal failure; consider additional doses of hepatitis B vaccine according to Ab level against HBsAg. Individuals w/ thrombocytopenia or bleeding disorder. Syncope may occur; place procedures to prevent falling & injury. +ve urine test can be observed w/in 1-2 wk following vaccination; perform other tests to confirm HIB infection during this period. Contains phenylalanine which may be harmful for individuals w/ phenylketonuria; K 39 mg/dose & Na 23 mg/dose. Not intended for women of childbearing age. Not applicable during pregnancy & lactation. Childn >24 mth; preterm infants (≤37 wk of gestation); HIV-exposed infants (infected & uninfected); consider resp monitoring for 48-72 hr in very premature infants (≤28 wk of gestation) particularly those w/ previous history of resp immaturity.
Sign Out
