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Indications and Dosage
Topical/Cutaneous
Haematoma, Superficial bruising, Superficial thrombophlebitis Adult: As 0.3% or 0.445% w/w cream and 0.3% w/w gel: Apply 3-5 cm ribbon (or up to 15 cm as necessary) to the affected areas up to 4 times daily.
Child: ≥5 years As 0.3% w/w cream/gel: Same as adult dose. |
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Contraindications
Application on large areas, sensitive areas of skin, broken skin, or mucous membranes.
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Special Precautions
Children. Pregnancy and lactation.
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Adverse Reactions
Immune system disorders: Hypersensitivity reaction.
Skin and subcutaneous tissue disorders: Erythema, local skin irritation. |
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Patient Counseling Information
Avoid smoking or exposure to fire or flames. Fabrics (e.g. clothing, dressings, beddings) that have been in contact with the product are more flammable. Washing clothes and bedding may lessen the risk of flammability but not eliminate it.
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Action
Description:
Mechanism of Action: Heparinoid is a term that includes heparin derivatives and is used more lightly to include naturally occurring and synthetic highly-sulfated polysaccharides of similar structure. It is a topical anticoagulant that promotes fibrinolysis via potentiation of urokinase activity resulting in its thrombolytic effect. It has an anti-inflammatory effect through weak inhibition of PGE2 synthesis and indirect influence on LTB4 production. Heparinoid also has an anti-exudative property that is brought by hyaluronidase inhibition. Pharmacokinetics: Absorption: Bioavailability: Up to 4.6% (absorbed non-locally) by various tissues. Excretion: Via urine (as heparinoid and depolymerised shorter chain length compounds). |
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Storage
Store below 30°C. Do not freeze.
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ATC Classification
C05BA - Heparins or heparinoids for topical use ; Used in antivaricose therapy.
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References
Anon. Mucopolysaccharide Polysulphate. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 26/10/2023. Buckingham R (ed). Heparinoids. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 26/10/2023. Hirudoid Cream (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 26/10/2023. Hirudoid Cream (Genus Pharmaceuticals Limited). MHRA. https://products.mhra.gov.uk. Accessed 26/10/2023. Hirudoid Forte Cream (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 26/10/2023. Hirudoid Gel (Genus Pharmaceuticals Limited). MHRA. https://products.mhra.gov.uk. Accessed 26/10/2023. Joint Formulary Committee. Heparinoid. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 26/10/2023. Paediatric Formulary Committee. Heparinoid. BNF for Children [online]. London. BMJ Group, Pharmaceutical Press, and RCPCH Publications. https://www.medicinescomplete.com. Accessed 26/10/2023.
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