Erdomed Mechanism of Action

Pharmaco-therapeutic group: medicines for cough and cold diseases. ATC code: R05CB15
Pharmacology: ERDOMED (erdosteine) acts pharmacologically as a fluidifying agent of bronchial mucus.
Pharmacodynamics: Mechanism of action/pharmacodynamic effects: Erdosteine, active ingredient of ERDOMED, in addition to its mucolytic properties on bronchial mucus thus facilitating expectoration, shows effects in antagonizing the local formation of free radicals and inhibiting the activity of the elastase enzyme.
Pharmacological studies have demonstrated that erdosteine does not possess these properties as such, but it is active only after metabolization. In fact, the SH groups, to which the activity is ascribed, are chemically used and become free only after metabolization or in alkaline environment. This property guarantees a good palatability with no bad taste and mercaptanic regurgitations and a good gastric tolerability.
Pharmacokinetics: Peak plasma concentration of the product occurs after 30-60 minutes.
Subsequent complete metabolization to similar metabolites.
Very good bioavailability by oral route.
Toxicology: Preclinical safety data: (See Table 1.)

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