View Eligard overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to leuprorelin acetate or to other GnRH agonists. Patients who previously underwent orchiectomy. Sole treatment in prostate cancer patients w/ spinal cord compression or evidence of spinal metastases. Women & childn.
Instructions for reconstitution & administration must be strictly followed. Patients w/ history or risk factors for QT prolongation; receiving concomitant QT-prolonging medicinal products; assess benefit-risk ratio including the potential for Torsade de Pointes prior to initiating treatment. Correct electrolyte abnormalities; consider periodic monitoring of ECG & electrolytes. Increased risk of developing MI, sudden cardiac death & stroke; monitor for signs & symptoms of CV disease. Transient increase in serum conc of testosterone, dihydrotestosterone & acid phosphatase during the 1st wk of treatment. Consider additional administration of an appropriate antiandrogen 3 days prior to treatment & continuing for the 1st 2-3 wk of treatment, to prevent sequelae of an initial rise in serum testosterone. Decreased bone density in men who had orchiectomy or those treated w/ GnRH agonist. Monitor for symptoms of pituitary apoplexy (eg, sudden headache, vomiting, visual changes, ophthalmoplegia, altered mental status & CV collapse). Hyperglycemia & increased risk of developing diabetes; periodically monitor blood glucose &/or HbA1c. Convulsions. Institute standard treatment if spinal cord compression or renal impairment develops. Closely monitor patients w/ vertebral &/or brain metastases as well as w/ urinary tract obstruction. May impair ability to drive or operate machines due to fatigue, dizziness & visual disturbances. Pregnancy & lactation. Childn 0-18 yr.
Concomitant use w/ known QT-prolonging medicinal products able to induce Torsade de Pointes eg, class IA (eg, quinidine, disopyramide procainamide) or class III (eg, amiodarone, sotalol, dofetilide, ibutilide) antiarrhythmics, methadone, moxifloxacin, antipsychotics.
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