Ecocort Mechanism of Action

Pharmacology: Pharmacodynamics: Econazole nitrate is an imidazole anti-fungal agent closely related to miconazole and with similar antifungal and antibacterial activity. Ergosterol is important to the integrity and function of the fungal cell membrane. The imidazoles inhibit the incorporation of acetate into ergosterol, and they also inhibit lanosterol demethylase. There is disorganisation and thickening of the plasmalemma. The uptake of essential nutrient is impaired. Such mechanism would explain the selectivity for fungi and low toxicity for mammalian cells, but it does not explain the actions on gram-positive bacteria, anaerobes, and trichomonads. Minimum inhibitory concentrations range from 0.12 to 25 microgram per mL. It is two to eight times more active than miconazole against filamentous fungi, minimal inhibitory concentrations lie between 0.025 and 12.5 microgram per mL. Econazole is especially active against the mycelial forms. Triamcinolone acetonide is a topically active fluorinated corticosteroid which has anti-inflammatory, antipruritic and vasoconstrictive actions.
Pharmacokinetics: Econazole Nitrate: Econazole readily penetrates the stratum and is found in effective concentrations down to the mid-demis. However, less than 1% of an applied dose appears to be absorbed into the blood. Following oral administration, about 40% of the dose is excreted in the urine and 30% is eliminated in faeces, in 5 days. A mean peak plasma concentration of 2.6 microgram per mL has been reported 2.5 hours after oral administration of 250 mg of econazole to 8 subjects.
Triamcinolone Acetonide: Topical corticosteriods have anti-inflammatory, anti-pruritic, and vasoconstrictive actions. When administered topically, particularly under occlusive dressings or when the skin is broken, sufficient corticosteroids may be absorbed to give systemic effects. Corticosteroids are extensively bound to plasma proteins. Only unbound corticosteroids have pharmacological effects or are metabolized. They are metabolized mainly in the liver, also in the kidneys, and are excreted in the urine.