Dynastat Contraindications

Parecoxib is contraindicated in: patients with known hypersensitivity to parecoxib or to any other ingredient of the product.
History of previous serious allergic drug reaction of any type, especially cutaneous reaction such as Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme or patients with known hypersensitivity to sulphonamides (see Precautions and Adverse Reactions).
Active peptic ulceration or gastrointestinal (GI) bleeding.
Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria, or other allergic-type reactions after taking acetylsalicylic acid (aspirin) or non-steroidal anti-inflammatory drugs (NSAIDs), including other COX-2 specific inhibitors.
The third trimester of pregnancy and breast-feeding.
Severe hepatic impairment (serum albumin <25 g/L or Child-Pugh Class C).
Inflammatory bowel disease.
Congestive heart failure (NYHA II-IV).
Treatment of post-operative pain following coronary artery bypass graft (CABG) surgery.
Established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease.