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No interaction studies have been performed.
Since maximum plasma concentrations of levofloxacin and dexamethasone after ocular administration are at least 1000 and 80 times lower than those reported after standard oral doses, respectively, interactions with other products for systemic use are unlikely to be clinically relevant.
The concomitant use of probenecid, cimetidine, or ciclosporin with levofloxacin altered some pharmacokinetic parameters of levofloxacin, but not to a clinically significant extent.
Concomitant use of topical steroids and topical NSAIDs may increase the potential for corneal healing problems.
CYP3A4 inhibitors (including ritonavir and cobicistat) may decrease dexamethasone clearance resulting in increased effects. The combination should be avoided unless the benefit outweighs the increased risk of systemic corticosteroid side-effects, in which case patients should be monitored for systemic corticosteroid effects.
