Diapro Mechanism of Action

Pharmacology: Pharmacodynamics: Gliclazide has pharmacological actions common to all sulfonylurea drugs. Their primary effect is to potentiate glucose-stimulated insulin release from functioning β-cells of pancreatic islets. The mechanism by which this occurs has been elucidated in recent years.
Pharmacokinetics: Gliclazide is well-absorbed. The mean plasma half-life is 10 h (6-14 h) and the volume of distribution is about 17-25 L (15-40% of body weight). About 95% (85-97%) of Gliclazide is bound to protein in plasma, mostly to Albumin. Gliclazide is extensively metabolized and less than 20% is excreted in the urine in unchanged form. The hydroxy metabolites can be subsequently glucuronidated. Gliclazide is oxidized in the body in both the azobicyclooctyl portion of the molecule, to produce either hydroxylated metabolites or N-oxygenated compounds, and in the P-tolyl grouping, to produce the corresponding alcohol and carboxylic acid.