Pharmacology: Triprolidine hydrochloride acts as an antagonists of the H1 histamine receptor. Pseudoephedrine acts as an indirect sympathomimetic agent by stimulating sympathetic nerve endings to release noradrenaline. Noradrenaline in turn stimulates alpha and beta receptors throughout the body. The action of pseudoephedrine hydrochloride is apparently more specific for the blood vessels of the upper respiratory tract and less specific for the blood vessels of the systemic circulation. The vasoconstriction elicited at these sites results in the shrinkage of swollen tissues in the sinuses and nasal passages.
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