Dapril Mechanism of Action

Lisinopril is an inhibitor of the angiotensin-converting enzyme (ACE) and inhibits the formation of angiotensin II, a powerful vasoconstrictor. Lisinopril modulates a specific physiological mechanism, the renin-angiotensin-aldosterone system, which plays a significant role in the regulation of blood pressure. Its onset of action begins within 2 hrs following oral administration, achieves its peak effect 4-6 hrs after an oral dose and its effects continue for at least 24 hrs after a single daily dose. Data indicate no loss of effect during long-term therapy. Rebound hypertension does not occur after abrupt cessation of treatment with ACE inhibitors.
Congestive heart failure patients treated with lisinopril benefit particularly from reduction in preload and afterload of the heart, with an increase in cardiac output, without reflex tachycardia.
Lisinopril is not significantly metabolized by the liver, has negligible plasma protein-binding and is excreted unchanged in the urine. Lisinopril minimizes the development of thiazide-induced hypokalaemia and hyperuricaemia.