Apo-Amitriptyline Dosage/Direction for Use

Orally Dosage should be initiated at a low level and increased gradually, noting carefully the clinical response and any evidence of intolerance.
Initial dose for adults: 25 mg 3 times a day. If necessary, increase dose preferably in the late afternoon and/or bedtime to total of 150 mg a day.
Hospitalized patients may require 100 mg a day initially, increased gradually to 200 mg a day, if necessary. A small number need as much as 300 mg a day.
Adolescent and elderly patients: In general, lower dosages recommended: 10 mg 3 times a day with 20 mg at bedtime may be satisfactory.
Maintenance dose is usually 25 mg 2 to 4 times a day. When satisfactory improvement has been reached, reduce to lowest amount that will maintain relief of symptoms.
Children: Not recommended for treatment of depression in children under 12 years of age.
Enuresis: 10 mg at bedtime for children under 6 years of age. In older children increase dosage as necessary up to 25 mg at bedtime.