APO-ALFUZOSIN (alfuzosin hydrochloride) is contraindicated in: hypersensitivity to alfuzosin and/or any of the other ingredients, postural hypotension, liver failure, severe kidney failure (creatinine clearance <30 ml/min), in combination with potent CYP3A4 inhibitors such as ketoconazole, ritonavir and itraconazole.