Amocla Drug Interactions

Probenecid decreases the renal excretion of amoxicillin. Concurrent use with AMOCLA may result in increased and prolonged blood levels of amoxicillin.
The concurrent administration of allopurinol and ampicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. But it is not known whether this potentiation of ampicillin rash is due to allopurinol or the hyperuricemia present in these patients.
AMOCLA should not be co-administered with disulfiram.
Prolongation of bleeding time and prothrombin time have been reported in some patients receiving AMOCLA.
Thus, this drug should be used with care in patients on anticoagulation therapy.
AMOCLA may reduce the effect of oral contraceptives, and the caution should be given to patients.
Laboratory test interactions: AMOCLA results in high urine concentration. High urine concentration of ampicillin may result in false-positive reactions when testing for the presence of glucose in urine using Clinitest, Benedict or Fehling's solution.