Zolid15 mg Management of Type 2 DM alone or in combination w/ metformin or a sulfonylurea. 30 mg Adjunct to diet & exercise to improve glycemic control in patients w/ NIDDM. Alone or used in combination w/ sulfonylurea, metformin or insulin when diet & exercise plus the single agent does not result in adequate glycemic control. ZolidPlus Type 2 DM when monotherapy is inadequate or for patients requiring combined or more intensive therapy.
ZolidMonotherapy 15 or 30 mg once daily. Combination therapy 15 or 30 mg once daily. Patient at risk of hypoglycemia or w/ hepatic impairment Max dose: 45 mg once daily. ZolidPlusPatient inadequately controlled on metformin monotherapy 15 mg/500 mg once or bid. Patient who initially responded to pioglitazone monotherapy & require additional glycemic control 15 mg/500 mg once or bid. Patient switching from combination therapy of pioglitazone plus metformin as separate tab 15 mg/500 mg once or bid.
Zolid Heart failure. IDDM (type I); treatment of diabetic ketoacidosis. ZolidPlus Cardiac failure or history of cardiac failure (NYHA class III or IV). Hepatic impairment or active liver disease, acute or chronic disease causing tissue hypoxia eg, cardiac or resp failure, recent MI, shock. Acute alcohol intoxication, alcoholism. Renal failure or dysfunction (CrCl <60 mL/min). Patients w/ type 1 DM or diabetic ketoacidosis.
Zolid Hypoglycemia, edema, anemia. Postmenopausal women. Active liver disease or increased serum transaminase levels. Pregnancy & lactation. Childn. ZolidPlus Cardiac failure. Therapy w/ pioglitazone may result in ovulation in some premenopausal anovulatory women. Monitor Hb. Therapy should not be initiated in patients w/ acute liver disease or ALT levels exceeds 2.5 times the ULN. Lactic acidosis. Discontinue use when CV collapse (shock), acute CHF & MI occur. Avoid excessive alcohol intake. Hypoglycemia when caloric intake is deficient, strenuous exercise is not compensated by caloric supplementation or concomitant use w/ hypoglycemic agents (eg, sulfonylurea or insulin) or ethanol.
A10BG03 - pioglitazone ; Belongs to the class of thiazolidinediones. Used in the treatment of diabetes. A10BD05 - metformin and pioglitazone ; Belongs to the class of combinations of oral blood glucose lowering drugs. Used in the treatment of diabetes.
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