Treatment of anaerobic infections due to Bacteroides fragilis including those involving the CNS eg, meningitis, brain abscess, endocarditis, intra-abdominal infections, sepsis. Treatment of antibiotic-induced pseudomembranous colitis due to C. difficile bacterial vaginosis (due to Gardnerella vaginalis). Prophylaxis of anaerobic infections associated w/ colorectal & gynecological surgery (usually in combination w/ aminoglycosides for the aerobes). Treatment of trichomoniasis, amebiasis & gardiasis. Part of combination therapy for H. pylori. Treatment of all forms of tetanus.
Adult & childn >12 yr 500 mg every 8 hr for 7 days. Childn <12 yr 7.5 mg/kg every 8 hr. Renal insufficiency interval extended to 12 hr. Duration of therapy should not exceed 10 days.
GI upset, burning sensation in the tongue, metallic taste, overgrowth of Candida, rash, urticaria. Headache, dizziness, somnolence, incoordination, depression. Drug fever, darkened urine, mild leukopenia. Peripheral neuropathy, myalgia & paresthesia after high doses.
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