The antihypertensive effects of losartan may be potentiated by drugs or other agents that lower blood pressure. Additive hyperkalaemic effect is possible with potassium supplements, potassium-sparring diuretics or other drugs that can cause hyperkalaemia; losartan a potassium-sparring diuretics should not generally be given together. NSAIDs should be used with caution in patients taking losartan as the risk of renal impairment may be increased, particularly in those who are inadequately hydrated; use of NSAIDs may also attenuate the hypotensive effect of losartan.
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