Usual dose: 50 mg once daily, may be increased up to 100 mg daily as a single dose or in 2 divided doses. Elderly >75 yr, patient w/ moderate to severe renal impairment (CrCl <20 mL/min) or intravascular fluid depletion Initially 25 mg once daily.
Antihypertensive effects may be potentiated by drugs or other agents that lower BP. Possible additive hyperkalaemic effect w/ K supplements, K-sparring diuretics or other drugs that can cause hyperkalaemia. Increased risk of renal impairment & may attenuate hypotensive effect w/ NSAIDs.
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