Verquvo Dosage/Direction for Use

Adults: The recommended starting dose of Vericiguat (Verquvo) is 2.5 mg once daily, taken with food.
Double the dose of Vericiguat (Verquvo) approximately every 2 weeks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient.
For patients who are unable to swallow whole tablets, Vericiguat (Verquvo) may be crushed and mixed with water immediately before administration [see Pharmacology: Pharmacokinetics under Actions].
Missed Dose: If a dose is missed, it should be taken as soon as the patient remembers on the same day of the missed dose. Patients should not take two doses of Vericiguat (Verquvo) on the same day.
Pediatric Patients: Safety and efficacy of Vericiguat (Verquvo) have not been established in patients less than 18 years of age [see Use in Children under Precautions and Pharmacology: Pharmacokinetics under Actions].
Geriatric Patients: No dosage adjustment of Vericiguat (Verquvo) is required for geriatric patients [see Use in the Elderly under Precautions and Pharmacology: Pharmacokinetics under Actions].
Renal Impairment: No dose adjustment of Vericiguat (Verquvo) is required in patients with estimated glomerular filtration rate (eGFR) ≥15 mL/min/1.73m² (without dialysis). Vericiguat (Verquvo) has not been studied in patients with eGFR <15 mL/min/1.73m² at treatment initiation or on dialysis and is therefore not recommended in these patients [see Renal Impairment under Precautions and Pharmacology: Pharmacodynamics: Clinical Studies and Pharmacokinetics under Action].
Hepatic Impairment: No dose adjustment of Vericiguat (Verquvo) is required in patients with mild or moderate hepatic impairment. Vericiguat (Verquvo) has not been studied in patients with severe hepatic impairment and is therefore not recommended in these patients [see Hepatic Impairment under Precautions and Pharmacology: Pharmacokinetics under Actions].