Urica Adverse Reactions

Adverse effects reported in 1% or more of patients receiving Febuxostat (Urica) include dizziness, liver function abnormalities, nausea, arthralgia and rash.
Less common adverse effects (<1% of patients) include: General: Asthenia, chest pain/discomfort, edema, fatigue, abnormal feeling, gait abnormality, influenza-like symptoms, mass pain, thirst.
Gastrointestinal: Abdominal distention, abnormal pain, constipation, dry mouth, dyspepsia, flatulence, frequent stools, gastritis, gastroesophageal reflux disease, gastrointestinal discomfort, gingival pain, hematemesis, Hyperchlorhydria, hematochezia, mouth ulceration, pancreatitis, peptic ulcer, vomiting.
Cardiac: Angina pectoris, atrial fibrillation/flutter, cardiac murmur, abnormal electrocardiogram, palpitations, sinus bradycardia, tachycardia, hypertension, hypotension, flushing.
Nervous System: Altered taste, balance disorder, cerebrovascular accident, Guillain-Barre syndrome, headache, hemiparesis, hypoesthesia, hyposmia, lacunar infarction, lethargy, mental impairment, migraine, paresthesia, somnolence, transient ischemic attack, tremor.
Psychiatric: Agitation, anxiety, depression, insomnia, irritability, decreased libido, nervousness, panic attack, personality change, psychotic behavior including aggressive thoughts.
Respiratory: Bronchitis, cough, dyspnea, epistaxis, nasal dryness, paranasal sinus hypersecretion, pharyngeal edema, respiratory tract congestion, sneezing, throat irritation, upper respiratory tract infection.
Hepatobiliary: Cholelithiasis/cholecystitis, hepatic steatosis, hepatitis, hepatomegaly.
Renal: Hematuria, nephrolithiasis, pollakiuria, proteinuria, renal failure, renal insufficiency, urgency, incontinence, tubulointerstitial nephritis.
Hematologic: Anemia, idiopathic thrombocytopenic purpura, leukocytosis/leukopenia, neutropenia, pancytopenia, splenomegaly, thrombocytopenia.
Metabolic/Endocrine: Anorexia, decreased/increased appetite, decreased/increased weight, dehydration, diabetes mellitus, hypercholesterolemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, hypokalemia.
Musculoskeletal: Arthritis, Joint stiffness, joint swelling, muscle spasms/twitching/tightness/weakness, musculoskeletal pain/ stiffness, myalgia, rhabdomyolysis.
Dermatologic: Alopecia, angioedema, dermatitis, dermographism, ecchymosis, eczema, hair color changes, abnormal hair growth hyperhidrosis, peeling skin, petechiae, photosensitivity, pruritus, purpura, skin discoloration/altered pigmentation, skin lesion, abnormal skin odor, urticaria, herpes zoster, generalized rash, Stevens-Johnson syndrome, skin hypersensitivity reactions.
Special senses: Deafness, tinnitus, vertigo, blurred vision.
Reproductive System and breast Changes: breast pain, erectile dysfunction, gynecomastia.
Immune System: Hypersensitivity, anaphylaxis, anaphylactic reaction.
Procedural Complications: Contusion.
Laboratory Parameters: Activated partial thromboplastin time prolonged, abnormal electroencephalopathy, abnormal coagulation lest, prolonged prothrombin time, urinary casts, urine positive for white blood cells and protein.
Increase in: Blood urea Nitrogen (BUN)/Creatinine ratio, Creatine phosphokinase, sodium, glucose, cholesterol, triglycerides, blood urea, amylase, potassium, thyroid-stimulating hormone, mean corpuscular volume, white blood cells, alkaline phosphatase, low-density lipoprotein, lactate dehydrogenase, prostate specific antigen, urine output.
Decrease in: Bicarbonate, platelet count, hematocrit, hemoglobin, red blood cells, white blood cells, urine output, lymphocyte count, neutrophil count.
Seek advice from a healthcare professional at the first sign of any adverse drug reaction.