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Increased toxicity w/ sympathomimetic agents (eg, epinephrine) & general anesth (eg, halothane). May result in hypertensive crisis w/ MAOIs (eg, selegeline, moclobemide) & antidepressants (eg, amitriptylline, imipramine).
Phenylpropanolamine: May produce additive increase in BP in combination w/ caffeine.
Dextromethorphan: CYP450 isoenzyme CYP2D6 inhibitors eg, amiodarone, haloperidol, quinidine, SSRIs & thioridazine. Symptoms of toxicity w/ amiodarone & quinidine. Additive CNS depression may occur w/ alcohol, antihistamines, psychotropics & other CNS depressants.
Paracetamol: May increase INR w/ warfarin. May increase susceptibility to the harmful effects of liver w/ medicines for convulsions (eg, phenobarb, phenytoin). Absorption may be accelerated by metoclopramide or domperidone & reduced by cholestyramine. Other paracetamol-containing product.
