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Use with caution in patients at risk of increased bleeding from trauma, surgery or other pathological condition, patients who have lesions with a propensity to bleed (eg, ulcer) and hepatic impairment.
Discontinue clopidogrel 7 days prior to surgery or any event when a normal platelet effect is needed.
Use with caution in patients taking medication that increased the risk of bleeding eg, nonsteroidal anti-inflammatory drugs (NSAIDs) or aspirin.
Use in pregnancy: Use in pregnancy only if it is clearly indicated.
Use in children: Clopidogrel is not approved for use in children.
