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Cautions on application: 1) A large volume of intravenous administration may cause rarely angioalgia, thrombophlebitis. The preparation of injectable solution, sites and methods of injection are considered with caution and administration should be done as slowly as possible (I.V.).
2) Vancomycin solution exhibits a physical incompatibility when mixed with a number of drugs, including ceftazidime. The likelihood of precipitation with ceftazidime is dependent on the concentrations of vancomycin and ceftazidime present. It is therefore recommended, when both drugs are to be administered by intermittent IV infusion, that they be given separately, flushing the IV lines (with 1 of the compatible IV fluids) between the administration of these 2 agents.
3) All vials of this drug as supplied are under reduced pressure. When ceftazidime is dissolved, carbon dioxide is released and a positive pressure develops.
4) Sodium bicarbonate injection is not used as a diluent.
5) Solutions of this drug should not be added to solutions of aminoglycoside antibiotics.
6) Distal necrosis can occur after inadvertent intra-arterial administration of ceftazidime.
Caution on storage: After reconstitution, this drug is used within 6 hours at temperatures not exceeding 30°C or within 72 hours under refrigeration (2-8°C).
Others: In domestic studies (2001), tolerance to this drug has been reported in 9% of Escherichia coli, 27% of Klebsiella pneumoniae, 44.0% of Enterobacter cloacae, 26% of Serratia marcescens, 21% of Pseudomonas aeruginosa and 65% of Acinetobacter.
