The most common adverse drug reactions in using etoricoxib include headache, rashes, blurred vision, difficulty in sleeping (insomnia), muscle cramps, fatigue, disturbances of the gut such as diarrhea, constipation, nausea, vomiting or abdominal pain, weight gain, ulceration of the stomach or intestine, cold or flu-like symptoms, dizziness, excessive fluid retention in the body tissues, resulting in swelling (edema), nosebleed (epistaxis), difficulty in breathing (dyspnea), weakness or loss of strength (asthenia), high blood pressure (hypertension), chest pain, anxiety and liver or kidney disorders.