Treatment with mefenamic acid should not be continued >7 days. Mefenamic acid is not recommended for use in children, pregnant women and nursing mothers. It should be used with caution in patients with impaired renal and liver function. Concomitant therapy with plasma-protein-binding drugs may require modification in dosage. If anticoagulants are being administered, the dose may need to be reduced. If skin rash, diarrhea or other significant gastrointestinal discomfort occurs, Mefenamic acid (Stangesic) should be discontinued and consultation with physician is advised.